Detalhe da pesquisa
1.
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients.
N Engl J Med
; 388(15): 1353-1364, 2023 Apr 13.
Artigo
Inglês
| MEDLINE | ID: mdl-36876740
2.
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia.
J Pharmacokinet Pharmacodyn
; 50(5): 351-364, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37243877
3.
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.
N Engl J Med
; 379(22): 2097-2107, 2018 11 29.
Artigo
Inglês
| MEDLINE | ID: mdl-30403574
4.
Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia.
Circulation
; 140(6): 470-486, 2019 08 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31242752
5.
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.
N Engl J Med
; 377(3): 211-221, 2017 07 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28538136
6.
Simulation of impact on cardiovascular events due to lipid-lowering therapy intensification in a population with atherosclerotic cardiovascular disease.
Am Heart J
; 216: 30-41, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31386936
7.
Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans.
Circulation
; 135(4): 352-362, 2017 Jan 24.
Artigo
Inglês
| MEDLINE | ID: mdl-27986651
8.
ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia.
N Engl J Med
; 377(3): 296-297, 2017 07 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28723334
9.
Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin.
J Lipid Res
; 55(10): 2103-12, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25139399
10.
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study.
Lancet
; 381(9860): 40-6, 2013 Jan 05.
Artigo
Inglês
| MEDLINE | ID: mdl-23122768
11.
Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial.
Am Heart J
; 168(5): 682-9, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25440796
12.
Potential Cardiovascular Events Avoided with Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared with Ezetimibe Alone in Patients with Atherosclerotic Cardiovascular Disease Taking Maximally Tolerated Statins.
Am J Cardiovasc Drugs
; 23(1): 67-76, 2023 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-36316612
13.
Bempedoic acid lowers high-sensitivity C-reactive protein and low-density lipoprotein cholesterol: Analysis of pooled data from four phase 3 clinical trials.
Atherosclerosis
; 373: 1-9, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37075696
14.
Pharmacokinetics of bempedoic acid in patients with renal impairment.
Clin Transl Sci
; 15(3): 789-798, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34800002
15.
Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose-response model.
Eur Heart J Cardiovasc Pharmacother
; 8(6): 578-586, 2022 Sep 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34448822
16.
Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers.
Clin Transl Sci
; 14(6): 2487-2496, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34463032
17.
Bempedoic acid safety analysis: Pooled data from four phase 3 clinical trials.
J Clin Lipidol
; 14(5): 649-659.e6, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32980290
18.
Pharmacodynamic relationship between PCSK9, alirocumab, and LDL-C lowering in the ODYSSEY CHOICE I trial.
J Clin Lipidol
; 14(5): 707-719, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32928709
19.
Simulation of the Impact of Statin Intolerance on the Need for Ezetimibe and/or Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor for Meeting Low-Density Lipoprotein Cholesterol Goals in a Population With Atherosclerotic Cardiovascular Disease.
Am J Cardiol
; 123(8): 1202-1207, 2019 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30736965
20.
Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease.
N Engl J Med
; 352(1): 29-38, 2005 Jan 06.
Artigo
Inglês
| MEDLINE | ID: mdl-15635110